A more efficient device for preparing model-membrane liposomes by the rapid solvent exchange method.

We modified the original design for a rapid solvent exchange (RSE) device with the intent of making the RSE method (i) more efficient and (ii) easier to adopt and implement. Our modifications improved solvent-removal kinetics by a factor of 2, while reducing sample-prep time by a factor of 3. In this paper, we develop the kinetic model that informed the device revision and we address several RSE parameters that have not yet been discussed in the literature. We also provide detailed mechanical drawings and present solvent-removal efficiency data that confirm the improved performance of our device.